A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury
Document Type
Article
Publication Date
5-1-2011
Abstract
We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat. © 2011 Elsevier Masson SAS. All rights reserved.
Publication Title
European Journal of Medicinal Chemistry
Recommended Citation
Bi, W.,
Bi, Y.,
Xue, P.,
Zhang, Y.,
Gao, X.,
Wang, Z.,
Li, M.,
Baudy-Floc'H, M.,
Ngerebara, N.,
Michael Gibson, K.,
&
Bi, L.
(2011).
A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury.
European Journal of Medicinal Chemistry,
46(5), 1453-1462.
http://doi.org/10.1016/j.ejmech.2011.01.021
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6317