Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles

Authors

Vellaisamy Selvaraj, Marshall University
Niraj Nepal, Marshall University
Steven Rogers, Marshall University
Nandini D.P.K. Manne, Marshall University
Ravikumar Arvapalli, Marshall University
Kevin M. Rice, Marshall University
Shinichi Asano, Marshall University
Erin Fankenhanel, Marshall University
J. Y. Ma, National Institute for Occupational Safety and Health
Tolou Shokuhfar, Michigan Technological UniversityFollow
Mani Maheshwari, Marshall University
Eric R. Blough, Marshall University

Document Type

Article

Publication Date

9-2015

Department

Department of Mechanical Engineering-Engineering Mechanics

Abstract

High mortality rates are associated with the life threatening disease of sepsis. Improvements in septic patient survivability have failed to materialize with currently available treatments. This article represents data regarding a study published in biomaterials (Vellaisamy et al., Biomaterials, 2015, in press). with the purpose of evaluating whether severe sepsis mortality and associated hepatic dysfunction induced by lipopolysaccharide (LPS) can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the method and processing of raw data related to our study publish in Biomaterials and Data in Brief (Vellaisamy et al., Biomaterials, 2015, in press; Vellaisamy et al., Data in Brief, 2015, in press.). The data contained in this article evaluates the contribution of MAPK signaling in LPS induced sepsis. Macrophage cells (RAW 264.7) were treated with a range of cerium oxide nanoparticle concentration in the presence and absence of LPS. Immunoblotting was performed on the cell lysates to evaluate the effect of cerium oxide nanoparticle treatment on LPS induced changes in Mitogen Activated Protein Kinases (MAPK) p-38, ERK 1/2, and SAPK/JNK phosphorylation.

Publisher's Statement

© 2015 The Authors. Publisher’s version of record: https://doi.org/10.1016/j.dib.2015.04.022

Publication Title

Data in Brief

Recommended Citation

Selvaraj, V., Nepal, N., Rogers, S., Manne, N., Arvapalli, R., Rice, K., Asano, S., Fankenhanel, E., Ma, J., Shokuhfar, T., Maheshwari, M., & Blough, E. (2015). Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles. Data in Brief, 4, 96-99. http://doi.org/10.1016/j.dib.2015.04.022
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6278

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Version

Publisher's PDF