Title

Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury

Document Type

Article

Publication Date

1-1-2016

Abstract

© 2016 We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function.

Publication Title

Bioorganic and Medicinal Chemistry Letters

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