Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury
© 2016 We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function.
Bioorganic and Medicinal Chemistry Letters
Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury.
Bioorganic and Medicinal Chemistry Letters,
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