Targeted fluorescent probes for detection of oxidative stress in the mitochondria
Document Type
Article
Publication Date
9-1-2015
Department
Department of Chemistry
Abstract
Mitochondrial oxidative stress has been implicated in aging, neurodegenerative diseases, diabetes, stroke, ischemia/reperfusion injury, age-related macular degeneration (AMD) and cancer. Recently, we developed two new mitochondria-targeting fluorescent probes, MitoProbes I/II, which specifically localize in mitochondria and employed both in vivo and in vitro for detection of mitochondrial oxidative stress. Here, we report the design and synthesis of these agents, as well as their utility for real-time imaging of mitochondrial oxidative stress in cells.
Publication Title
Bioorganic and Medicinal Chemistry Letters
Recommended Citation
Yapici, N.,
Mandalapu, S.,
Michael Gibson, K.,
&
Bi, L.
(2015).
Targeted fluorescent probes for detection of oxidative stress in the mitochondria.
Bioorganic and Medicinal Chemistry Letters,
25(17), 3476-3480.
http://doi.org/10.1016/j.bmcl.2015.07.011
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6055