Design, synthesis and cardioprotective effect of a new class of dual-acting agents: Phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates
Document Type
Article
Publication Date
11-15-2007
Department
Department of Chemistry
Abstract
In this study, a new class of phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates was designed and synthesized. The radical scavenging activities of these newly synthesized compounds 12a-c were evaluated in PC12 cell survival assays. The NO scavenging activities of these compounds were confirmed in the acetylcholine-induced vasorelaxation assay. Compounds 12a-c were efficacious in a rat arterial thrombosis model, and were active in ADP- or PAF-induced in vitro platelet aggregation assays, which suggests these compounds also possess anti-thrombotic activity. The beneficial effects of dual-acting agent 12c were demonstrated on the ischemia-reperfusion induced cardiac infarct size and oxidative change in an in vivo rat model.
Publication Title
Bioorganic and Medicinal Chemistry
Recommended Citation
Bi, W.,
Cai, J.,
Liu, S.,
Baudy-Floc'h, M.,
&
Bi, L.
(2007).
Design, synthesis and cardioprotective effect of a new class of dual-acting agents: Phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates.
Bioorganic and Medicinal Chemistry,
15(22), 6909-6919.
http://doi.org/10.1016/j.bmc.2007.08.022
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/6051