Bioactive vapor deposited calcium-phosphate silica sol–gel particles for directing osteoblast behavior
Document Type
Article
Publication Date
9-1-2016
Department
Department of Biomedical Engineering
Abstract
Silica-based materials are being developed and used for a variety of applications in orthopedic tissue engineering. In this work, we characterize the ability of a novel silica sol vapor deposition system to quickly modify biomaterial substrates and modulate surface hydrophobicity, surface topography, and composition. We were able to show that surface hydrophobicity, surface roughness, and composition could be rapidly modified. The compositional modification was directed towards generating apatitic-like surface mineral compositions (Ca/P ratios ∼1.30). Modified substrates were also capable of altering cell proliferation and differentiation behavior of preosteoblasts (MC3T3) and showed potential once optimized to provide a simple means to generate osteo-conductive substrates for tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2135–2148, 2016.
Publication Title
Journal of Biomedical Materials Research - Part A
Recommended Citation
Snyder, K.,
Holmes, H.,
McCarthy, C.,
&
Rajachar, R.
(2016).
Bioactive vapor deposited calcium-phosphate silica sol–gel particles for directing osteoblast behavior.
Journal of Biomedical Materials Research - Part A,
104(9), 2135-2148.
http://doi.org/10.1002/jbm.a.35746
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/3686
Publisher's Statement
© 2016 Wiley Periodicals, Inc. Publisher’s version of record: https://doi.org/10.1002/jbm.a.35746