Highly enantioselective organocatalytic hydroxyalkylation of indoles with ethyl trifluoropyruvate
Document Type
Article
Publication Date
5-13-2005
Department
Department of Chemistry
Abstract
(Chemical Equation Presented) Readily available cinchona alkaloids have been used as organocatalysts in the highly efficient stereoselective hydroxyalkylation of heteroaromatics such as indoles with 3,3,3- trifluoropyruvate (2, see scheme). High yields and ee values of both enantiomers of the products, depending on the catalyst used, indicate the usefulness of the developed methodology.
Publication Title
Angewandte Chemie - International Edition
Recommended Citation
Török, B.,
Abid, M.,
London, G.,
Esquibel, J.,
Török, M.,
Mhadgut, S.,
Yan, P.,
&
Prakash, G.
(2005).
Highly enantioselective organocatalytic hydroxyalkylation of indoles with ethyl trifluoropyruvate.
Angewandte Chemie - International Edition,
44(20), 3086-3089.
http://doi.org/10.1002/anie.200462877
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/3485