Controlling the Release of Hydrogen Peroxide from Catechol-Based Adhesives Using Silica Nanoparticles
Document Type
Article
Publication Date
6-28-2020
Department
Department of Biomedical Engineering; Department of Materials Science and Engineering
Abstract
Catechol-based bioadhesives generate hydrogen peroxide (H2O2) as a byproduct during the curing process. H2O2 can have both beneficial and deleterious effects on biological systems depending on its concentration. To control the amount of H2O2 released from catechol-containing polyethylene glycol-based adhesive (PEG-DA), an adhesive was formulated with silica nanoparticles (SiNPs) prepared with increased porosity and acid treatment to increase Si-OH surface content. These SiNPs demonstrated increased surface area, which promoted interaction with catechol and resulted in an increased cure rate, bulk mechanical properties, and adhesive properties of PEG-DA. Most importantly, the SiNPs demonstrated a 50% reduction in the released H2O2 while improving the cell viability and proliferation of three primary cell types, including rat dermal fibroblasts, human epidermal keratinocytes, and human tenocytes. Additionally, the SiNPs degraded into soluble Si, which also contributed to increased cell proliferation. Incorporation of porous and acid-treated SiNPs can be a useful approach to simultaneously modulate the concentration of H2O2 while increasing the adhesive performance of catechol-based adhesives.
Publication Title
ACS Biomaterials Science and Engineering
Recommended Citation
Pinnaratip, R.,
Forooshani, P.,
Li, M.,
Hu, Y.,
Rajachar, R.,
&
Lee, B.
(2020).
Controlling the Release of Hydrogen Peroxide from Catechol-Based Adhesives Using Silica Nanoparticles.
ACS Biomaterials Science and Engineering,
6(8), 4502-4511.
http://doi.org/10.1021/acsbiomaterials.0c00572
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/2804
Publisher's Statement
© 2020 American Chemical Society. Publisher’s version of record: https://doi.org/10.1021/acsbiomaterials.0c00572