Degradation of Fungal MicroRNAs Triggered by Short Tandem Target Mimics Is via the Small-RNA-Degrading Nuclease.

Yulong Wang, Michigan Technological University
Zhangxun Wang, Anhui Agricultural University
Wenjing Yang, Anhui Agricultural University
Xiangyun Xie, Anhui Agricultural University
Haiyan Cheng, Anhui Agricultural University
Li Qin, Anhui Agricultural University
Guiliang Tang, Michigan Technological University
Bo Huang, Anhui Agricultural University

Abstract

MicroRNAs (miRNAs) have been recognized as sequence-specific regulators of the genome, transcriptome, and proteome in eukaryotes. However, the functions and working mechanisms of hundreds of fungal miRNA-like (miR-like) RNAs are obscure. Here, we report that a short tandem target mimic (STTM) triggered the degradation of several fungal miR-like RNAs in two different fungal species,