Document Type
Article
Publication Date
3-28-2023
Department
Department of Biomedical Engineering
Abstract
Elastic laminae, an elastin-based, layered extracellular matrix structure in the media of arteries, can inhibit leukocyte adhesion and vascular smooth muscle cell proliferation and migration, exhibiting anti-inflammatory and anti-thrombogenic properties. These properties prevent inflammatory and thrombogenic activities in the arterial media, constituting a mechanism for the maintenance of the structural integrity of the arterial wall in vascular disorders. The biological basis for these properties is the elastin-induced activation of inhibitory signaling pathways, involving the inhibitory cell receptor signal regulatory protein α (SIRPα) and Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1). The activation of these molecules causes deactivation of cell adhesion- and proliferation-regulatory signaling mechanisms. Given such anti-inflammatory and anti-thrombogenic properties, elastic laminae and elastin-based materials have potential for use in vascular reconstruction.
Publication Title
Bioengineering
Recommended Citation
Goldman, J.,
Liu, S.,
&
Tefft, B.
(2023).
Anti-Inflammatory and Anti-Thrombogenic Properties of Arterial Elastic Laminae.
Bioengineering,
10(4).
http://doi.org/10.3390/bioengineering10040424
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/17116
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Version
Publisher's PDF
Publisher's Statement
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. Publisher’s version of record: https://doi.org/10.3390/bioengineering10040424