TCT-380 Predicting Device-Related Thrombosis Using Computational Fluid Dynamics
Document Type
Article
Publication Date
8-20-2022
Department
Department of Biomedical Engineering
Abstract
Background
A common prevention method for left atrial appendage (LAA)-related cardioembolic stroke is occlusion of the appendage. A significant adverse event from this procedure is the development of device-related thrombosis (DRT). The aim of this study is to computationally evaluate the hemodynamic profiles of the left atrium in patients who have received an LAA occlusion (LAAO) device and to identify potential predictors for DRT.
Methods
Digital 3-dimensional patient-specific models were created from computed tomographic images. Finite element analysis performed by FEops was used to deploy a WATCHMAN device (Boston Scientific Corporation) in each model. Computational fluid dynamic simulations were performed on the patient-specific models (pre- and postdevice implantation). The resulting velocity streamlines and wall shear stress (WSS) were assessed. An example workflow is shown in Figure 1A.
Results
The LAAO device average WSS was lower for the DRT patients (1 and 0.45 Pa) than the control patients (2.5 and 4 Pa) (Figure 1B). An increase in atrial velocity from pre- to postimplantation was observed in only the control patients.
Publication Title
Journal of the American College of Cardiology
Recommended Citation
Vogl, B.,
El Shaer, A.,
Ponce, A. C.,
Bavo, A.,
De Beule, M.,
Alkhouli, M.,
&
Hatoum, H.
(2022).
TCT-380 Predicting Device-Related Thrombosis Using Computational Fluid Dynamics.
Journal of the American College of Cardiology,
80(12), B153.
http://doi.org/10.1016/j.jacc.2022.08.446
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/16818