Document Type
Article
Publication Date
5-31-2022
Department
College of Computing
Abstract
Background: Using single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) with phase analysis (PA), we aimed to identify the predictive value of a new contraction pattern in cardiac resynchronization therapy (CRT) response. Methods: Left ventricular mechanical dyssynchrony (LVMD) was evaluated using SPECT MPI with PA in non-ischemic dilated cardiomyopathy (DCM) patients with left bundle branch block (LBBB) indicated for CRT. CRT super-response was defined as LV ejection fraction (EF) ≥50% or an absolute increase of LVEF >15%. The LV contraction was categorized as the mild dyssynchronous pattern when the phase standard deviation (PSD) ≤ 40.3° and phase histogram bandwidth (PBW) ≤ 111.9°, otherwise it was defined as severe dyssynchronous pattern which was further characterized as U-shaped, heterogeneous or homogenous pattern. Results: The final cohort comprised 74 patients, including 32 (43.2%) in mild dyssynchronous group, 17 (23%) in U-shaped group, 19 (25.7%) in heterogeneous group, and 6 (8.1%) in homogenous group. The mild dyssynchronous group had lower PSD and PBW than U-shaped, heterogeneous, and homogenous groups ( < 0.0001). Compared to patients with the heterogeneous pattern, the odds ratios (ORs) with 95% confidence intervals (CIs) for CRT super-response were 10.182(2.43-42.663), 12.8(2.545-64.372), and 2.667(0.327-21.773) for patients with mild dyssynchronous, U-shaped, and homogenous pattern, respectively. After multivariable adjustment, mild dyssynchronous group remained associated with increased CRT super-response (adjusted OR 5.709, 95% CI 1.152-28.293). Kaplan-Meier curves showed that mild dyssynchronous group demonstrated a better long-term prognosis. Conclusions: The mild dyssynchronous pattern in patients with DCM is associated with an increased CRT super-response and better long-term prognosis.
Publication Title
Frontiers in cardiovascular medicine
Recommended Citation
Hu, X.,
Qian, Z.,
Zou, F.,
Xue, S.,
Zhang, X.,
Wang, Y.,
Hou, X.,
Zhou, W.,
&
Zou, J.
(2022).
A Mild Dyssynchronous Contraction Pattern Detected by SPECT Myocardial Perfusion Imaging Predicts Super-Response to Cardiac Resynchronization Therapy.
Frontiers in cardiovascular medicine,
9, 906467.
http://doi.org/10.3389/fcvm.2022.906467
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/16180
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
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Publisher's PDF
Publisher's Statement
© 2022 Hu, Qian, Zou, Xue, Zhang, Wang, Hou, Zhou and Zou. Publisher’s version of record: https://doi.org/10.3389/fcvm.2022.906467