Document Type
Article
Publication Date
4-25-2022
Department
Department of Biological Sciences; Department of Mechanical Engineering-Engineering Mechanics
Abstract
Ehlers-Danlos Syndromes (EDSs) are a group of connective tissue disorders, characterized by skin stretchability, joint hypermobility and instability. Mechanically, various tissues from EDS patients exhibit lowered elastic modulus and lowered ultimate strength. This change in mechanics has been associated with EDS symptoms. However, recent evidence points toward a possibility that the comorbidities of EDS could be also associated with reduced tissue stiffness. In this review, we focus on mast cell activation syndrome and impaired wound healing, comorbidities associated with the classical type (cEDS) and the hypermobile type (hEDS), respectively, and discuss potential mechanobiological pathways involved in the comorbidities.
Publication Title
Frontiers in Cell and Developmental Biology
Recommended Citation
Royer, S.,
&
Han, S.
(2022).
Mechanobiology in the Comorbidities of Ehlers Danlos Syndrome.
Frontiers in Cell and Developmental Biology,
10.
http://doi.org/10.3389/fcell.2022.874840
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/16011
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Version
Publisher's PDF
Publisher's Statement
© 2022 Royer and Han. Publisher’s version of record: https://doi.org/10.3389/fcell.2022.874840