Document Type


Publication Date



Department of Biomedical Engineering


Mussel foot proteins (Mfps) contain a large amount of the catecholic amino acid, DOPA, allowing the marine organism to anchor themselves onto various surfaces in a turbulent and wet environment. Modification of polymers with catechol imparts these materials with a strong, wet adhesive property. The oxidation chemistry and oxidation state of catechol are critical to the design of synthetic adhesives and biomaterials. In this Mini-Review, the effect of catechol oxidation state on adhesion, oxidation-mediated catechol cross-linking, and the generation of reactive oxygen species (ROS) during catechol oxidation are reviewed. Finally, the tuning of catechol oxidation state in designing stimuli-responsive adhesives and the utilization of ROS byproducts for antimicrobial and antiviral applications are reviewed.

Publisher's Statement

© 2021 The Authors. Published by. American Chemical Society. Publisher’s version of record:

Publication Title

ACS Omega


Publisher's PDF



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.