Document Type
Article
Publication Date
10-15-2020
Department
College of Computing
Abstract
Multi-omics studies, which explore the interactions between multiple types of biological factors, have significant advantages over single-omics analysis for their ability to provide a more holistic view of biological processes, uncover the causal and functional mechanisms for complex diseases, and facilitate new discoveries in precision medicine. However, omics datasets often contain missing values, and in multi-omics study designs it is common for individuals to be represented for some omics layers but not all. Since most statistical analyses cannot be applied directly to the incomplete datasets, imputation is typically performed to infer the missing values. Integrative imputation techniques which make use of the correlations and shared information among multi-omics datasets are expected to outperform approaches that rely on single-omics information alone, resulting in more accurate results for the subsequent downstream analyses. In this review, we provide an overview of the currently available imputation methods for handling missing values in bioinformatics data with an emphasis on multi-omics imputation. In addition, we also provide a perspective on how deep learning methods might be developed for the integrative imputation of multi-omics datasets.
Publication Title
Frontiers in Genetics
Recommended Citation
Song, M.,
Greenbaum, J.,
Luttrell, J.,
Zhou, W.,
Wu, C.,
Shen, H.,
Gong, P.,
Zhang, C.,
&
Deng, H.
(2020).
A Review of Integrative Imputation for Multi-Omics Datasets.
Frontiers in Genetics,
11.
http://doi.org/10.3389/fgene.2020.570255
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/14374
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Version
Publisher's PDF
Publisher's Statement
© Copyright © 2020 Song, Greenbaum, Luttrell, Zhou, Wu, Shen, Gong, Zhang and Deng. Publisher’s version of record: https://doi.org/10.3389/fgene.2020.570255