Cerebellar atrophy in human and murine succinic semialdehyde dehydrogenase deficiency
Document Type
Article
Publication Date
12-1-2010
Abstract
Human succinic semialdehyde dehydrogenase deficiency, an autosomal recessive disorder of γ-aminobutyric acid (GABA) catabolism, was modeled by a murine model sharing the phenotype of ataxia and seizures. Magnetic resonance imaging (MRI) with volumetry was obtained on 7 patients versus controls, and MRI with stereology was derived in 3 murine genotypes: null, wild-type, and heterozygous mutants. All patients had T1 hypointensity and T2 hyperintensity in globus pallidus, and 5 also had similar changes in subthalamic and cerebellar dentate nuclei. There was a trend for patients to have a smaller cerebellar vermis. Homozygous null mice had significantly lower total brain and cerebellar volumes than wild-types and heterozygotes. Stereology confirmed cerebellar atrophy and was otherwise normal in multiple regions. Cerebellar volume loss is present in the murine disorder with a trend for cerebellar atrophy in patients. Reduced cerebellar volume can reflect neurodegeneration and may be related to the clinical manifestations. © 2010 The Author(s).
Publication Title
Journal of Child Neurology
Recommended Citation
Acosta, M.,
Munasinghe, J.,
Pearl, P.,
Gupta, M.,
Finegersh, A.,
Gibson, K.,
&
Theodore, W.
(2010).
Cerebellar atrophy in human and murine succinic semialdehyde dehydrogenase deficiency.
Journal of Child Neurology,
25(12), 1457-1461.
http://doi.org/10.1177/0883073810368137
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/12859
