Molecular tools for facilitative carbohydrate tansporters (Gluts)
Document Type
Article
Publication Date
6-21-2017
Department
Department of Chemistry
Abstract
Facilitative carbohydrate transporters—Gluts—have received wide attention over decades due to their essential role in nutrient uptake and links with various metabolic disorders, including diabetes, obesity, and cancer. Endeavors directed towards understanding the mechanisms of Glut‐mediated nutrient uptake have resulted in a multidisciplinary research field spanning protein chemistry, chemical biology, organic synthesis, crystallography, and biomolecular modeling. Gluts became attractive targets for cancer research and medicinal chemistry, leading to the development of new approaches to cancer diagnostics and providing avenues for cancer‐targeting therapeutics. In this review, the current state of knowledge of the molecular interactions behind Glut‐mediated sugar uptake, Glut‐targeting probes, therapeutics, and inhibitors are discussed.
Publication Title
ChemBioChem Reviews
Recommended Citation
Tanasova, M.,
&
Fedie, J.
(2017).
Molecular tools for facilitative carbohydrate tansporters (Gluts).
ChemBioChem Reviews,
18(18), 1774-1788.
http://doi.org/10.1002/cbic.201700221
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/1278