Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells

Authors

Jianheng Bi, Michigan Technological UniversityFollow
Mingxi Fang, Michigan Technological UniversityFollow
Jianbo Wang, Jiaxing University
Shuai Xia, Michigan Technological UniversityFollow
Yibin Zhang, Michigan Technological UniversityFollow
Jingtuo Zhang, Michigan Technological University
Giri K. Vegesna, Michigan Technological University
Shuwei Zhang, Michigan Technological University
Marina Tanasova, Michigan Technological UniversityFollow
Fen-Tair Luo, Academia Sinica
Haiying Liu, Michigan Technological UniversityFollow

Document Type

Article

Publication Date

6-20-2017

Department

Department of Chemistry

Abstract

A new near-infrared fluorescent probe (NIR-PbP) for sensitive detection of Pb(II) ions in solution and living cells has been rationally designed and synthesized. The NIR-PbP is inherently non-fluorescent and gains fluorescence in the presence Pb(II) ions. The ion detection is based on Pb(II)-induced unmasking the fluorophore through the opening of the spyrocycle, with more than 500-fold fluorescence enhancement for sub-micromolar Pb(II) concentration. The NIR-PbP has high sensitivity, good photo-stability, low detection limit, and reversible response to Pb(II) ions.

Recommended Citation

Bi, J., Fang, M., Wang, J., Xia, S., Zhang, Y., Zhang, J., Vegesna, G. K., Zhang, S., Tanasova, M., Luo, F., & Liu, H. (2017). Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells. , 468(14), 140-145 http://doi.org/10.1016/j.ica.2017.06.044
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/1277