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Date of Award
Campus Access Master's Thesis
Master of Science in Chemistry (MS)
Administrative Home Department
Department of Chemistry
Committee Member 1
Tarum K. Dam
Committee Member 2
Fluorescent probes have become a powerful tool for scientists to selectively detect a wide variety of substances in living cells due to their simplicity and high sensitivity, enabling scientists to monitor them and to understand their physiological and pathological processes. A constant lysosomal pH is a prerequisite for more than 70 kinds of hydrolytic enzymes in lysosomes from all eukaryotic cells to function well, while zinc (II) ions play a vital role in numerous cellular metabolism. Abnormal lysosomal pH and Zn (II) ions concentration in cells always associate with many serious diseases. However, the emission and excitation peak of the most fluorescent probes are in the visible range which cause some issues, such as photo damage to cells and high fluorescence background. Therefore, novel near-infrared fluorescent probes for selectively detecting lysosomal pH and Zn (II) ions, respectively, with good aqueous solubility were developed to overcome these limitations.
Li, Cong, "NEAR-INFRARED WATER-SOLUBLE FLUORESCENT PROBES FOR THE DETECTION OF LYSOSOMAL pH AND Zn (II) IONS", Campus Access Master's Thesis, Michigan Technological University, 2016.