Date of Award

2021

Document Type

Campus Access Master's Report

Degree Name

Master of Science in Biomedical Engineering (MS)

Administrative Home Department

Department of Biomedical Engineering

Advisor 1

Jingfeng Jiang

Committee Member 1

Hoda Hatoum

Committee Member 2

Weihua Zhou

Abstract

Two studies were conducted applying computational fluid dynamics (CFD) using “patient-specific” data to further the understanding of abdominal aortic aneurysms (AAAs) and aortic dissections. In Study 1, AAAs were studied to develop a predictive model that could differentiate fast (>5 mm/year) and slow (/year) growing aneurysms. The purpose of Study 2 was to provide a CFD methodology for type I and type II aortic dissections, then to compare wall shear stress (WSS) values between the two types. Computational hemodynamics were studied in 25 patient data samples for Study 1 and 6 patient data samples in Study 2 by running CFD simulations. Both objectives were met, with the predictive model in Study 1 having 77% total accuracy, and Study 2 was able to demonstrate the feasibility of creating “patient-specific” aortic dissection models that indicated there is no significant difference between type I and type II spatiotemporally averaged WSS values.

Available for download on Monday, December 05, 2022

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