Document Type
Article
Publication Date
11-2024
Department
Department of Biomedical Engineering
Abstract
Magnesium (Mg) – based alloys are becoming attractive materials for medical applications as temporary bone implants for support of fracture healing, e.g. as a suture anchor. Due to their mechanical properties and biocompatibility, they may replace titanium or stainless-steel implants, commonly used in orthopedic field. Nevertheless, patient safety has to be assured by finding a long-term balance between metal degradation, osseointegration, bone ultrastructure adaptation and element distribution in organs. In order to determine the implant behavior and its influence on bone and tissues, we investigated two Mg alloys with gadolinium contents of 5 and 10 wt percent in comparison to permanent materials titanium and polyether ether ketone. The implants were present in rat tibia for 10, 20 and 32 weeks before sacrifice of the animal. Synchrotron radiation-based micro computed tomography enables the distinction of features like residual metal, degradation layer and bone structure. Additionally, X-ray diffraction and X-ray fluorescence yield information on parameters describing the bone ultrastructure and elemental composition at the bone-to-implant interface. Finally, with element specific mass spectrometry, the elements and their accumulation in the main organs and tissues are traced. The results show that Mg-xGd implants degrade in vivo under the formation of a stable degradation layer with bone remodeling similar to that of Ti after 10 weeks. No accumulation of Mg and Gd was observed in selected organs, except for the interfacial bone after 8 months of healing. Thus, we confirm that Mg-5Gd and Mg-10Gd are suitable material choices for bone implants.
Publication Title
Bioactive Materials
Recommended Citation
Iskhakova, K.,
Cwieka, H.,
Meers, S.,
Helmholz, H.,
Davydok, A.,
Storm, M.,
Baltruschat, I.,
Galli, S.,
Pröfrock, D.,
Will, O.,
Gerle, M.,
Damm, T.,
Sefa, S.,
He, W.,
MacRenaris, K.,
Soujon, M.,
Beckmann, F.,
Moosmann, J.,
O'Hallaran, T.,
Guillory, R.,
Wieland, D.,
Zeller-Plumhoff, B.,
&
Willumeit-Römer, R.
(2024).
Multi-modal investigation of the bone micro- and ultrastructure, and elemental distribution in the presence of Mg-xGd screws at mid-term healing stages.
Bioactive Materials,
41, 657-671.
http://doi.org/10.1016/j.bioactmat.2024.07.019
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/1043
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Version
Publisher's PDF
Publisher's Statement
© 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. Publisher’s version of record: https://doi.org/10.1016/j.bioactmat.2024.07.019