Date of Award
Open Access Master's Thesis
Master of Science in Biomedical Engineering (MS)
Administrative Home Department
Department of Biomedical Engineering
Committee Member 1
Committee Member 2
Karyn A. Fay
Bacterial infections continue to be a problem at the site of an indwelling medical device, and over the years, various bacterial strains have become more resistant to current antibiotic treatments. Bacterial infection at an indwelling medical device can be dangerous and affect the performance of the medical device which can ultimately lead to the failure of the device due to bacterial resistance to treatment.
Nitric Oxide (NO) has been shown to possess antibacterial properties to prevent and inhibit bacterial growth. NO releasing coatings on indwelling medical devices could provide a reduction in bacterial infections that occur at the device site such as for use in a urinary catheter. This work demonstrated that 1.7 x 10-8 moles of NO delivered over 18 hours prevented the growth and proliferation of Staphylococcus epidermidis, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Escherichia coli using S-Nitroso-N-acetyl-D-penicillamine linked to polydimethylsiloxane (SNAP-PDMS). It was also demonstrated that this effect is highly localized, with NO affecting bacteria only directly touching the polymer films. This localization should prevent systemic effects commonly observed with oral antibiotics when fabricating devices such as urinary catheters.
Osborne, Julia, "INHIBITION OF BACTERIAL GROWTH AND PREVENTION OF BACTERIAL ADHESION WITH LOCALIZED NITRIC OXIDE DELIVERY", Open Access Master's Thesis, Michigan Technological University, 2016.
Bacteria Commons, Bacterial Infections and Mycoses Commons, Bacteriology Commons, Biological Engineering Commons, Biology and Biomimetic Materials Commons, Biomaterials Commons, Biomedical and Dental Materials Commons, Immunology of Infectious Disease Commons, Infectious Disease Commons, Medical Immunology Commons, Medical Microbiology Commons, Polymer and Organic Materials Commons