Synthetic oligodeoxynucleotide purification by polymerization of failure sequences

Authors

Shiyue Fang, Michigan Technological UniversityFollow
Suntara Fueangfung, Michigan Technological University
Xi Lin, Michigan Technological University
Xiang Zhang, Michigan Technological University
Wenpeng Mai, Michigan Technological University
Lanrong Bi, Michigan Technological UniversityFollow
Sarah A. Green, Michigan Technological UniversityFollow

Document Type

Article

Publication Date

11-17-2010

Abstract

Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramiditefollowed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drugpurification.

Publisher's Statement

© Royal Society of Chemistry. Publisher's version of record: http://dx.doi.org/10.1039/C0CC04374E

Publication Title

Chemical Communications

Recommended Citation

Fang, S., Fueangfung, S., Lin, X., Zhang, X., Mai, W., Bi, L., & Green, S. A. (2010). Synthetic oligodeoxynucleotide purification by polymerization of failure sequences. Chemical Communications, 47(4), 1345-1347. http://doi.org/10.1039/C0CC04374E
Retrieved from: https://digitalcommons.mtu.edu/chemistry-fp/86