Title
Injectable dopamine-modified poly(ethylene glycol) nanocomposite hydrogel with enhanced adhesive property and bioactivity
Document Type
Article
Publication Date
9-14-2014
Abstract
A synthetic mimic of mussel adhesive protein, dopamine-modified four-armed poly(ethylene glycol) (PEG-D4), was combined with a synthetic nanosilicate, Laponite (Na0.7+(Mg5.5Li0.3Si8)O20(OH)4)0.7–), to form an injectable naoncomposite tissue adhesive hydrogel. Incorporation of up to 2 wt % Laponite significantly reduced the cure time while enhancing the bulk mechanical and adhesive properties of the adhesive due to strong interfacial binding between dopamine and Laponite. The addition of Laponite did not alter the degradation rate and cytocompatibility of PEG-D4 adhesive. On the basis of subcutaneous implantation in rat, PEG-D4 nanocomposite hydrogels elicited minimal inflammatory response and exhibited an enhanced level of cellular infiltration as compared to Laponite-free samples. The addition of Laponite is potentially a simple and effective method for promoting bioactivity in a bioinert, synthetic PEG-based adhesive while simultaneously enhancing its mechanical and adhesive properties.
Publication Title
Applied Materials and Interfaces
Recommended Citation
Liu, Y.,
Meng, H.,
Konst, S.,
Sarmiento, R.,
Rajachar, R.,
&
Lee, B. P.
(2014).
Injectable dopamine-modified poly(ethylene glycol) nanocomposite hydrogel with enhanced adhesive property and bioactivity.
Applied Materials and Interfaces,
6(19), 16982-16992.
http://doi.org/10.1021/am504566v
Retrieved from: https://digitalcommons.mtu.edu/biomedical-fp/13
Publisher's Statement
© 2014 American Chemical Society. Publisher's version of record: http://dx.doi.org/10.1021/am504566v