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Proteins are large biomolecules consisting one or more long chain of amino acid residues. Proteins perform a wide variety of functions within organisms including catalyzing metabolic activities, signal transduction, and transportation of molecules. They function differently from one another as their sequences of amino acids and also due to a variation of modification placed on residues. Change in modification patterns will impact protein interaction with other molecules, thus influence normal cell activities and may lead to disease development. In order to study the consequences of modification, we have a method to prepare proteins with desired modification patterns. Using the technique, how residue modification affects proteins’ interaction with others can be investigated at a molecular level.
Tajiri, Momoko, "Designing proteins for biomechanical and molecular biological studies" (2017). TechTalks. 48.