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In vivo, real-time measurement of local environmental parameters such as strain, pressure, temperature, pH, oxygen tension and specific biomarkers can be valuable for regenerative medicine research and therapies. Wireless implantable sensors are an attractive approach for certain regenerative medicine applications due to its relative simplicity and low cost. Presented here are such two implantable sensors. The first sensor is based on a miniature wireless sensor network that can digitize physical and chemical parameters and continuously stream measurements to a nearby receiver via a 2-way communication protocol. With the incorporation of a strain gauge, this sensor platform was applied to record mechanical loading at an internal fixation plate across a segmental femoral critical-size defect of a rat. The second sensor is based on a wireless, passive (battery-less) capacitive-inductive (LC) sensor. This sensor is being developed for detection of bone infection associated with orthopedic implants by monitoring local temperature variations.


Biomedical Engineering and Bioengineering

Implantable sensors for regenerative medicine



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