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Protein aggregates are hallmark of several age related disorders including neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer’s and Parkinson’s disease. However, the underlying mechanisms by which these aggregated proteins impair cellular functions and cause toxicity is not clear. I will discuss efforts from my laboratory to characterize these misfolded and aggregated protein structures and their associated toxicity.
Tiwari, Ashutosh, "Understanding the role of protein misfolding in neurodegenerative diseases" (2017). TechTalks. 40.