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There has been increasing efforts to translate laboratory blood tests analysis into portable, reliable, and cheap miniaturized devices. Electrokinetic-based microfluidic devices provide a new approach to blood tests with a simple infrastructure for the manipulation of cells. Previous studies show red blood cells’ (RBC) dielectrophoretic response changes based on the different ABO-Rh antigens present in the cells membrane. In this research, an alternate-current electric signal with a frequency sweep (0.1 – 1 MHz) is applied through an array of electrodes to generate non-uniform electric fields and induce dielectrophoretic forces on RBC from all eight blood types. The RBC’s response to the signal is recorded to perform an intensity analysis and generate a real-time profile describing each blood-type characteristic dielectrophoretic behavior over the frequency sweep. These results demonstrate that RBC with different membrane antigens have distinctive dielectrophoretic profiles, which could be used to rapidly differentiate blood types for point-of-care testing in emergency field applications.
Biomedical Engineering and Bioengineering
Moncada-Hernandez, Hector, "Point-of-Care microfluidic device for blood typing" (2016). TechTalks. 4.