Polycaprolactone-chitosan-based scaffolds with nanostructured cuprorivaite fabricated via 3D printing for bone tissue engineering
Document Type
Article
Publication Date
10-15-2025
Department
Department of Materials Science and Engineering
Abstract
Recently, there has been significant interest in using three-dimensional (3D) printed scaffolds for tissue engineering. In this study, scaffolds were created using a combination of polycaprolactone, chitosan, and cuprorivaite (PCL/CS/5–30 wt% Cup) through a 3D printing process. The resulting PCL/CS/5–30 wt% Cup scaffolds exhibited a rectangular, porous, and interconnected structure, with contact angle ranging from 68 ± 2° to 80 ± 4°. The addition of cuprorivaite only slightly affected the pore sizes. The compressive strength of the PCL/CS/Cup scaffolds reached approximately 22 ± 3 MPa, compared to 17 ± 2 MPa for the PCL/CS scaffolds. Additionally, the composite scaffolds demonstrated improved antibacterial performance against both Gram-positive and Gram-negative bacteria, as well as enhanced hydrophilicity and bioactivity. These findings suggest that 3D bioprinting has considerable potential for producing PCL/CS/Cup composite scaffolds suitable for bone tissue engineering (BTE), with enhanced bioactivity and antibacterial properties.
Publication Title
Materials Letters
Recommended Citation
Najafinezhad, A.,
Nasiri-Harchegani, S.,
Drelich, J.,
Arefi, R.,
Keshavarz, M.,
&
Bakhsheshi-Rad, H.
(2025).
Polycaprolactone-chitosan-based scaffolds with nanostructured cuprorivaite fabricated via 3D printing for bone tissue engineering.
Materials Letters,
397.
http://doi.org/10.1016/j.matlet.2025.138808
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p2/1763