Comparison of cerebral technetium-99m-ethyl cysteinate dimer perfusion in patients with dementia with Lewy bodies and Parkinson's disease dementia

Document Type

Article

Publication Date

12-23-2024

Department

Department of Mathematical Sciences; Department of Applied Computing

Abstract

Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are closely related neurodegenerative conditions within the Lewy body spectrum. The relationship between DLB and PDD remains debated, with ongoing discussion about whether they are distinct diseases or different manifestations of the same disorder. This study aimed to identify differences in cerebral perfusion patterns between DLB and PDD patients. Single-photon emission computed tomography ethyl cysteinate dimer imaging was performed on each patient, and relative tracer uptake levels across 47 regions of interest and 240 subregions were analyzed. A two-sided Welch's t-test was employed to evaluate mean perfusion differences, with results further confirmed through a voxel-wise t-test mapping. The greatest difference in perfusion was in the visual cortices, with lower mean perfusion observed in PDD patients than those with DLB. However, no comparisons remained significant at the 0.05 significance level after adjusting for multiple comparisons with the Benjamini-Hochberg procedure.

Publication Title

Nuclear Medicine Communications

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