Title

Aggregation of Β -amyloid fragments

Document Type

Article

Publication Date

1-15-2007

Abstract

The authors study the folding and aggregation of six chains of the Β -amyloid fragment 16-22 using Monte Carlo simulations. While the isolated fragment prefers a helical form at room temperature, in the system of six interacting fragments one observes both parallel and antiparallel Β sheets below a crossover temperature Tx ≈420 K. The antiparallel sheets have lower energy and are therefore more stable. Above the nucleation temperature the aggregate quickly dissolves into widely separated, weakly interacting chains. © 2007 American Institute of Physics.

Publication Title

Journal of Chemical Physics

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