Structure-function relationships in KDM7 histone demethylases.
Department of Chemistry
The demethylation of lysine residues of histone proteins is a key epigenetic mechanism in cells. The enzymes that catalyze these processes are called histone demethylases (KDMs). The largest family of KDMs is the Jumonji C (JmjC) domain-containing enzymes; these includes KDM2-7 subfamily of enzymes. The JmjC proteins are Fe(II) and 2-Oxoglutarate (2OG) - dependent dioxygenases that couple substrate oxidation to decarboxylation of 2OG to form succinate and CO
Adv Protein Chem Struct Biol
Structure-function relationships in KDM7 histone demethylases..
Adv Protein Chem Struct Biol,
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/846