Title

Scalable synthetic oligodeoxynucleotide purification with use of a catching by polymerization, washing, and releasing approach

Document Type

Article

Publication Date

8-20-2010

Abstract

Synthetic oligodeoxynucleotides are purified with use of a catching by polymerization, washing, and releasing approach. The method does not require any chromatography, and purification is achieved by simple operations such as shaking, washing, and extraction. It is therefore useful for large-scale purification of synthetic oligonucleotide drugs. In addition to purification of oligonucleotides, this catching by polymerization concept is expected to be equally useful for purification of other synthetic oligomers such as peptides and oligosaccharides. © 2010 American Chemical Society.

Publication Title

Organic Letters

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