Pd-Ir Core-Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic
Document Type
Article
Publication Date
10-27-2015
Abstract
© 2015 American Chemical Society. Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have been actively developed recently, limited progress has been made toward improving their catalytic efficiency. In this study, we report a type of highly efficient peroxidase mimic that was engineered by depositing Ir atoms as ultrathin skins (a few atomic layers) on Pd nanocubes (i.e., Pd-Ir cubes). The Pd-Ir cubes exhibited significantly enhanced efficiency, with catalytic constants more than 20- and 400-fold higher than those of the initial Pd cubes and horseradish peroxidase (HRP), respectively. As a proof-of-concept demonstration, the Pd-Ir cubes were applied to the colorimetric enzyme-linked immunosorbent assay (ELISA) of human prostate surface antigen (PSA) with a detection limit of 0.67 pg/mL, which is ∼110-fold lower than that of the conventional HRP-based ELISA using the same set of antibodies and the same procedure.
Publication Title
ACS Nano
Recommended Citation
Xia, X.,
Zhang, J.,
Lu, N.,
Kim, M.,
Ghale, K.,
Xu, Y.,
McKenzie, E.,
Liu, J.,
&
Ye, H.
(2015).
Pd-Ir Core-Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic.
ACS Nano,
9(10), 9994-10004.
http://doi.org/10.1021/acsnano.5b03525
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/7840