Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups
© 2016 American Chemical Society. By use of 1,3-dithian-2-yl-methoxycarbonyl (Dmoc) as a protecting group and linker for oligodeoxynucleotide (ODN) synthesis, deprotection and cleavage are achieved under non-nucleophilic oxidative conditions. The nucleophile-sensitive thioester and α-chloroacetyl groups are conveniently incorporated into ODN sequences. The technology could be universally useful for electrophilic ODN synthesis.
Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups.
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