Title

Parallel, Large-Scale, and Long Synthetic Oligodeoxynucleotide Purification Using the Catching Full-Length Sequence by Polymerization Technique

Document Type

Article

Publication Date

9-21-2018

Abstract

© 2018 American Chemical Society. The catching by polymerization synthetic oligodeoxynucleotide (ODN) purification technique was shown to be potentially suitable for high-throughput purification by the purification of 12 ODNs simultaneously, to be convenient for large-scale purification by purification at the 60 μmol synthesis scale, and to be highly powerful for purification of long ODNs by purification of ODNs as long as 303-mers. LC-MS analysis indicated that the ODNs purified with the technique have excellent purity.

Publication Title

Organic Process Research and Development

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