Title

Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by < sup> 19 F NMR spectroscopy

Document Type

Article

Publication Date

4-18-2005

Abstract

The determination of the enantiomeric composition of α- trifluoromethylated-hydroxyl compounds using cinchona alkaloids as chiral selectors is described. The interaction between the alkaloid and trifluoromethylated-hydroxyl compounds converted the enantiotopic nuclei to diastereotopic nuclei observed by 19F NMR spectroscopy. A wide variety of target molecules have been studied to highlight the broad applicability of the method. © 2005 Elsevier Ltd. All rights reserved.

Publication Title

Tetrahedron Asymmetry

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