Title

Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat

Document Type

Article

Publication Date

6-1-2011

Abstract

We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.

Publication Title

European Journal of Medicinal Chemistry

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