Bioengineering scaffolds for regenerative engineering

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Department of Biomedical Engineering


Tissue engineering and regenerative medicine have been vastly developing since the past decade. Cell, scaffold, and signal are the tissue engineering triad. In that, the scaffold is critical to supporting tissue regeneration. The purpose of scaffolding is to mimic the structure and function of extracellular matrix in native tissues, which replaces, or partially replaces, damaged or diseased tissues. This article will provide a broad summary of scaffolding materials and fabrication techniques. Different scaffolding materials including synthetic, natural, and hybrid materials are introduced in detail. Fabrication techniques including decellularization, particulate leaching, gas foaming, phase separation, electrospinning, and three-dimensional printing are evaluated as methods to effectively recreate the architecture of target tissues. Examples of scaffold applications in regenerative therapies are given, while the specific requirements of architecture, material properties, and biochemical properties are discussed.

Publication Title

Encyclopedia of Biomedical Engineering