Title

Synthesis of dextroamphetamine sulfate and methamphetamine hydrochloride from D‐phenylalanine

Document Type

Article

Publication Date

1-1-1978

Abstract

Starting from D‐phenylalanine, dextroamphetamine sulfate and methamphetamine hydrochloride were synthesized. The reaction sequence proceeds through three intermediates, in which the absolute configuration of the asymmetric carbon atom is changed but the relative configuration remains the same. Either product can be obtained from a common intermediate by altering the reductive conditions employed for the removal of a carbamate protecting group. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company

Publication Title

Journal of Pharmaceutical Sciences

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