Title

Highly enantioselective organocatalytic hydroxyalkylation of indoles with ethyl trifluoropyruvate

Document Type

Article

Publication Date

5-13-2005

Abstract

(Chemical Equation Presented) Readily available cinchona alkaloids have been used as organocatalysts in the highly efficient stereoselective hydroxyalkylation of heteroaromatics such as indoles with 3,3,3- trifluoropyruvate (2, see scheme). High yields and ee values of both enantiomers of the products, depending on the catalyst used, indicate the usefulness of the developed methodology. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

Publication Title

Angewandte Chemie - International Edition

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