Title

A near-infrared fluorescent probe based on a hemicyanine dye with an oxazolidine switch for mitochondrial pH detection

Document Type

Article

Publication Date

12-8-2020

Department

Department of Chemistry

Abstract

A near-infrared fluorescent probe (AH+) has been prepared by incorporating an oxazolidine switch into a near-infrared hemicyanine dye. The probe shows fast and sensitive responses to pH from an oxazolidine switch to the hemicyanine dye upon pH decreases from 10.0 to 5.0. The probe shows good photostability, low cytotoxicity, and reversible fluorescence responses to pH changes with a pKa value of 7.6. It has been successfully used to determine pH changes in mitochondria.

Publisher's Statement

© The Royal Society of Chemistry. Publisher’s version of record: https://doi.org/10.1039/d0tb02181d

Publication Title

Journal of Materials Chemistry B

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