A near-infrared fluorescent probe based on a hemicyanine dye with an oxazolidine switch for mitochondrial pH detection

Authors

Wafa Mazi, Michigan Technological UniversityFollow
Yunnan Yan, Michigan Technological UniversityFollow
Yibin Zhang, Michigan Technological UniversityFollow
Shuai Xia, Michigan Technological University
Shulin Wan, Michigan Technological UniversityFollow
Momoko Tajiri, Michigan Technological UniversityFollow
Rudy Luck, Michigan Technological UniversityFollow
Haiying Liu, Michigan Technological UniversityFollow

Document Type

Article

Publication Date

12-8-2020

Department

Department of Chemistry

Abstract

A near-infrared fluorescent probe (AH+) has been prepared by incorporating an oxazolidine switch into a near-infrared hemicyanine dye. The probe shows fast and sensitive responses to pH from an oxazolidine switch to the hemicyanine dye upon pH decreases from 10.0 to 5.0. The probe shows good photostability, low cytotoxicity, and reversible fluorescence responses to pH changes with a pKa value of 7.6. It has been successfully used to determine pH changes in mitochondria.

Publisher's Statement

© The Royal Society of Chemistry. Publisher’s version of record: https://doi.org/10.1039/d0tb02181d

Publication Title

Journal of Materials Chemistry B

Recommended Citation

Mazi, W., Yan, Y., Zhang, Y., Xia, S., Wan, S., Tajiri, M., Luck, R., & Liu, H. (2020). A near-infrared fluorescent probe based on a hemicyanine dye with an oxazolidine switch for mitochondrial pH detection. Journal of Materials Chemistry B, 9(3), 857-863. http://doi.org/10.1039/d0tb02181d
Retrieved from: https://digitalcommons.mtu.edu/michigantech-p/14607