Cyber-physical integration in programmable microfluidic biochips

Document Type

Conference Proceeding

Publication Date



© 2015 IEEE. Microfluidic biochip technology integrates miniaturized components into a chip that can perform traditional biochemical laboratory procedures. Commercial impact is highlighted by the recent acquisition of Advanced Liquid Logic by Illumina Inc., a leader in DNA sequencing and biomolecular analysis. Due to the inherent variability involved in many biochemical processes, uncertainties manifest themselves in many ways in microluidics. Cyber-physical integration of on-chip sensors permits feedback-driven monitoring in-real time to detect and correct errors, along with other benefits such as adaptive control and dynamic re-synthesis. This paper overviews low-based and digital (droplet-based) microluidic biopchips, and discusses the state-of-The-Art in microluidic device fabrication, the interplay between sensor feedback and adaptive control software, and practical experiences relating to biochip cyber-physical integration. It demonstrates the connections between the many fundamental principles of chip design and engineering, and the needs of the biochip community.

Publication Title

Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015