Explore a collection of works from Michigan Technological University's Department of Kinesiology and Integrative Physiology.

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Submissions from 2024

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Acetic Acid: An Underestimated Metabolite in Ethanol-Induced Changes in Regulating Cardiovascular Function, Andrew D. Chapp, Zhiying Shan, and Qing Hui Chen

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Aerobic exercise improves depressive symptoms in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease, Hannah Loughlin, Jacob Jackson, Chloe Looman, Alayna Starll, Jeremy Goldman, Zhiying Shan, and Chunxiu Yu

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Influences of backpack loading on recovery from anterior and posterior losses of balance: An exploratory investigation, Jessica Pitts, Vicki Komisar, Kayley Elmblad, Alyssa Smith, Derek Verbrigghe, Carly Siko, Maury A. Nussbaum, and Carolyn A Duncan

Michigan Tech Open Education Week Panel Discussion, Linda Wanless, Michael Maxwell, Matthew Barron, Breanne Carlson, and Annelise Doll

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Innovative Cyanine-Based Fluorescent Dye for Targeted Mitochondrial Imaging and Its Utility in Whole-Brain Visualization, Xin Yan, Xinqian Chen, Zhiying Shan, and Lanrong Bi

Submissions from 2023

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Conductive 3D nano-biohybrid systems based on densified carbon nanotube forests and living cells, Roya Bagheri, Alicia K. Ball, Masoud Kasraie, Aparna Chandra, Xinqian Chen, Ibrahim Miskioglu, Zhiying Shan, and Parisa Pour Shahid Saeed Abadi

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Core Body Temperature Changes Prior to Sleep are Associated with Nocturnal Heart Rate Variability, Jeremy A. Bigalke, Emily L. Cleveland, Elyse Barkstrom, Joshua E. Gonzalez, and Jason R. Carter

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Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans, Jeremy A. Bigalke, John J. Durocher, Ian M. Greenlund, Manda Keller-Ross, and Jason R. Carter

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Ethanol Metabolite, Acetate, Increases Excitability of the Central Nucleus of Amygdala Neurons through Activation of NMDA Receptors, Andrew Chapp, Andréa R. Collins, Kyle Michael Driscoll, Jessica Behnke, Zhiying Shan, Li Zhang, and Qing-Hui Chen

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Physiological and perceptual responses to acute arm cranking with blood flow restriction, Benjamin Cockfield, Isaac J. Wedig, Alyssa L. Vinckier, John McDaniel, and Steve Elmer

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Reply to Surapaneni, Steve Elmer, Cassandra R. Gohn, John J. Durocher, and Naveen Sharma

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Promoting Outreach Through Physiology Chapter Collaboration, Steve Elmer, Cassandra R. Gohn, John J. Durocher, and Naveen Sharma

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Physical Activity and Cardiorespiratory Fitness as Modulators of Health Outcomes: A Compelling Research-Based Case Presented to the Medical Community, Barry A. Franklin, Isaac J. Wedig, Robert E. Sallis, Carl J. Lavie, and Steve Elmer

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Acute fasting reduces tolerance to progressive central hypovolemia in humans, Joshua E. Gonzalez and William H. Cooke

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10th Annual Michigan Physiological Society Meeting: June 26-27, 2023, Brianna D. Harfmann, Steven Elmer, Jennifer R. Vranish, Subha Bhaskaran, John F. Zubek, Kevin Gordish, Andrew Butcko, Christopher M. Westercamp, Harold J. Bell, and Naveen Sharma

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Single-leg cycling to maintain and improve function in healthy and clinical populations, C. Eric Heidorn, Steve Elmer, Kyle W. Wehmanen, James C. Martin, and John McDaniel

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Revealing the catalytic strategy of FTO, Ann Varghese, Sodiq Waheed, Shobhit Chaturvedi, Isabella DiCastri, Ciara LaRouche, Brenden Kaski, Nicolai Lehnert, Deyu Li, Christo Christov, and Tatyana Karabencheva-Christova

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Catalytic Mechanism of Collagen Hydrolysis by Zinc(II)-Dependent Matrix Metalloproteinase-1, Ann Varghese, Sodiq Waheed, Koteswararao Gorantla, Isabella DiCastri, Ciara LaRouche, Brenden Kaski, Gregg B. Fields, and Tatyana Karabencheva-Christova

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Blood flow restriction as a potential therapy to restore physical function following COVID-19 infection, Isaac J. Wedig, John J. Durocher, John McDaniel, and Steve Elmer

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Development of a prediction equation to estimate lower-limb arterial occlusion pressure with a thigh sphygmomanometer, Isaac J. Wedig, Isaac Lennox, Erich Petushek, John McDaniel, John J. Durocher, and Steve Elmer

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Promoting Physical Activity in Rural Communities During COVID-19 with Exercise is Medicine®on Campus, Isaac J. Wedig, Jamie J. Phillips, Kelly Kamm, and Steve Elmer

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The Impact of Health Behaviors on Community Wellbeing and Resilience: Teaching K-12 Students Using Jenga!, Kyle W. Wehmanen, Felix E. Cottet-Puinel, Tyler C. Hampton, Gwyn T. Hamlin, Isaac J. Wedig, and Steve Elmer

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Engineering Exosomes to Specifically Target the Mitochondria of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, and Lanrong Bi

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Engineering Exosomes to Specifically Target the Mitochondria of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, and Lanrong Bi

Works from 2022

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Orexin, Sleep, Sympathetic Neural Activity, and Cardiovascular Function, Jeremy A. Bigalke, Zhiying Shan, and Jason R. Carter

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Single Prolonged Stress Alters Vasopressin and Orexin System Expression in Sprague Dawley Rats, Xinqian Chen, Lily VanLoon, Sophia Bancker, Qinghui Chen, and Zhiying Shan

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Beyond the Baroreflex: A New Measure of Autonomic Regulation Based on the Time-Frequency Assessment of Variability, Phase Coherence and Couplings, Philip T. Clemson, Jeffrey B. Hoag, William H. Cooke, Dwain L. Eckberg, and Aneta Stefanovska

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Control of Orthodontic Tooth Movement by Nitric Oxide Releasing Nanoparticles in Sprague-Dawley Rats, Derrick Crawford, Tommy C. Lau, Megan C. Frost, and Nan E. Hatch

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Leading at the Edge During COVID-19: Challenges, Opportunities, and Future Pandemic Preparedness, Steve Elmer and Kelly Kamm

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Promoting physical activity during the COVID-19 pandemic in a rural and medically underserved region, Steve Elmer, Isaac J. Wedig, Isaac Lennox, and Kelly Kamm

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Acute Fasting Decreases Tolerance to Lower Body Negative Pressure, Joshua E. Gonzalez and William H. Cooke

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Influence of an acute fast on ambulatory blood pressure and autonomic cardiovascular control, Joshua Eric Gonzalez and William H. Cooke

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Morning Cardiovascular and Sympathetic Reactivity to Cold Pressor Test After Evening Binge Drinking: Sex Differences, Ian M. Greenlund, Jeremy A. Bigalke, Anne L. Tikkanen, Jennifer R. Nicevski, Carl Smoot, John J. Durocher, and Jason R. Carter

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Commentaries on Viewpoint: Musings on mentoring: teach your "children" well, Lisa T. Jansen, Nicholas P. Greene, Joy Camarao, Martin J. MacInnis, Cari Din, Steve Elmer, and Isaac J. Wedig

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Physiological Responses to Acute Cycling With Blood Flow Restriction, Matthew A. Kilgas, Tejin Yoon, John McDaniel, Kevin Phillips, and Steve Elmer

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SK Channel Dysfunction in the Hypothalamic Paraventricular Nucleus Contributes to Sympathoexcitation in Dahl Salt-Sensitive Rats, Robert Larson, Xinqian Chen, Mingjun Gu, Zhiying Shan, and Qinghui Chen

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Exercise Training Upregulates SK+ Channel Function in the Hypothalamic Paraventricular Nucleus (PVN) of Animals, Gregory Miodonski, Jessica Bruning, Christian Johnson, Mingjun Gu, Zhiying Shan, and Qing Hui Chen

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Neural and muscular alterations of the plantar flexors in middle-aged women, Kevin C. Phillips, Byungjoo Noh, Matthew Gage, Tejin Yoon, and Tejin Yoon

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Commentaries on Viewpoint: COVID-19 controls causing a kerfuffle, Mohammed S. Razzaque, Suhaila Karim Jaser, Raul Cosme Prado, Kaitlin A. Freeberg, Katelyn R. Ludwig, Daniel H. Craighead, Matthew J. Rossman, Anumeha Bhagat, Joshua M. Bock, Chad C. Wiggins, Jonathon W. Senefeld, Isaac J. Wedig, Steve Elmer, and Kelly Kamm

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9th Annual Michigan Physiological Society Meeting: June 17-18, 2022, Jennifer R. Vranish, Steven Elmer, Brianna D. Harfmann, Naveen Sharma, M Beth Zimmer, Harold J. Bell, Kevin Gordish, and Subha Bhaskaran

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Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1, Sodiq Waheed, Tatyana G. Karabencheva-Christova, Bella DiCastri, Brenden Kaski, Ciara LaRouche, and Gregg B. Fields

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Post-Exercise Arterial Stiffness Responses Are Similar After Acute Eccentric and Concentric Arm Cycling, Travis Wakeham, Dakota J. Anderson, Steven J. Elmer, and John J. Durocher

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A Practical Application of Blood Flow Restriction Exercise, Isaac J. Wedig, Isaac Lennox, Carmen J. Scarfone, and Steve Elmer

Works from 2021

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Activation of Orexin 1 Receptors in the Paraventricular Nucleus Contributes to the Development of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation of Vasopressin, Jeremy Bigalke, Huanjia Gao, Qing Hui Chen, and Zhiying Shan

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Blunted heart rate recovery to spontaneous nocturnal arousals in short-sleeping adults, Jeremy Bigalke, Ian Greenlund, Jennifer R. Nicevski, Carl A. Smoot, Benjamin Oosterhoff, Neha A. John-Henderson, and Jason R. Carter

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Commentaries on Viewpoint: The academic biomedical research laboratory as a "small business", Abhinav Dixit, Neelesh Gehlot, Andrea Becchetti, Jarrod A. Call, Sarah M. Greising, João Paulo Vilas-Boas, Ricardo J. Fernandes, Steven J. Elmer, Isaac J. Wedig, Ashley L. Hawke, Carmen J. Scarfone, and Isaac M. Lennox

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Rural Community Health: Keeping Michigan's Upper Peninsula Informed During the COVID-19 Pandemic, Steve Elmer, Lydia Lytle, and Kelly Kamm

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Metabolic power and efficiency for an amputee cyclist: Implications for cycling technique, Steve Elmer and James C. Martin

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8th Annual Michigan Physiological Society Meeting: June 24-25, 2021, Steve Elmer, Jennifer R. Vranish, Brianna D. Harfmann, Naveen Sharma, John J. Durocher, M Beth Zimmer, and Harold J. Bell

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Activation of Orexin System Stimulates CaMKII Expression, Yuanyuan Fan, Enshe Jiang, Huanjia Gao, Jeremy Bigalke, Bojun Chen, Chunxiu Yu, Qinghui Chen, and Zhiying Shan

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TNFα Triggers an Augmented Inflammatory Response in Brain Neurons from Dahl Salt-Sensitive Rats Compared with Normal Sprague Dawley Rats, Huanjia Gao, Jeremy Bigalke, Enshe Jiang, Yuanyuan Fan, Bojun Chen, Qing Hui Chen, and Zhiying Shan

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Acute effects of electronic cigarettes on arterial pressure and peripheral sympathetic activity in young nonsmokers, Joshua E. Gonzalez and William H. Cooke

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Controlled breathing and autonomic rhythms: Influence of auditory versus visual cues, Joshua Gonzalez, Stephanie R. Jewell, Steven Stelly, and William H. Cooke

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Acute Fasting Increases Vagal Tone and Reduces Ambulatory Arterial Pressure, Joshua Gonzalez, Steven Stelly, and William H. Cooke

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Morning sympathetic activity after evening binge alcohol consumption, Ian M. Greenlund, Hannah Cunningham, Anne L. Tikkanen, Jeremy A. Bigalke, Carl Smoot, John J. Durocher, and Jason R. Carter

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Sex differences in blood pressure responsiveness to spontaneous K-complexes during stage II sleep, Ian Greenlund, Carl Smoot, and Jason R. Carter

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Building a healthier information environment during COVID-19, Ashley L. Hawke, Xinqian Chen, Isaac M. Lennox, Carmen J. Scarfone, Isaac J. Wedig, Jamie J. Phillips, Kelly Kamm, and Steve Elmer

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Noncircular Chainrings Do Not Influence Physiological Responses During Submaximal Cycling, Chee Hoi Leong, Steve Elmer, and James C. Martin

Works from 2020

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Acetylation of Aβ42 at Lysine 16 Disrupts Amyloid Formation., Rashmi Adhikari, Mu Yang, Nabanita Saikia, Colina Dutta, Wafa Fhad A Alharbi, Zhiying Shan, Ravindra Pandey, and Ashutosh Tiwari

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Sex differences in self-report anxiety and sleep quality during COVID-19 stay-at-home orders, Jeremy Bigalke, Ian Greenlund, and Jason R. Carter

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Spotlight On: Microbiome, Jessica Bruning and Qinghui Chen

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Microbial Derived Short Chain Fatty-Acids and Autonomic Regulation of Cardiovascular Function, Jessica Bruning, Ryan B. Ghannam, Qing-Hui Chen, Zhiying Shan, Gregory Miodonski, Stephen Techtmann, and Andrew D. Chapp

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Subjective and objective sleep differ in male and female collegiate athletes., Jason R. Carter, Brett M Gervais, Janelle L Adomeit, and Ian Greenlund

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Elevated L-lactate Promotes Major Cellular Pathologies Associated with Neurodegenerative Diseases, Andrew Chapp, Jessica Behnke, Kyle Michael Driscoll, Taija Marie Hahka, Zoe LaLonde, Zhiying Shan, and Qing Hui Chen

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Cardiovascular Disease in Women Across the Lifespan: The Importance of Sleep., Stacie L Daugherty, Jason R. Carter, and Ghada Bourjeily

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The Effect of Wave Motion Intensities on Performance in a Simulated Search and Rescue Task and the Concurrent Demands of Maintaining Balance, Carolyn A Duncan, Nicole Bishop, Vicki Komisar, Scott N. MacKinnon, and Jeannette M. Byrne

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Plasma Orexin A Level is Increased in Salt-Sensitive Hypertension, Huanjia Gao, Jeremy Bigalke, Cassie Bloch, Qinghui Chen, Bojun Chen, and Zhiying Shan

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Acute effects of the JUUL e‐cigarette on blood pressure and peripheral sympathetic activity in young non‐smokers, Joshua Eric Gonzalez, Stephanie Renee Jewell, and William H. Cooke

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Influence of acute fasting on cerebrovascular reactivity during mental stress, Joshua Eric Gonzalez, Steven Philip Stelly, and William H. Cooke

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Enhanced store-operated calcium entry in platelets is associated with acute coronary syndrome., Xin Guo, Jiayu Zhang, Jianhua Zhu, Qing-Hui Chen, Renjun Wang, and Le Gui

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Developing a science outreach program and promoting "PhUn" all year with rural K-12 students., Jana L Hendrickson, Thomas K. Bye, Benjamin Cockfield, Kathryn R. Carter, and Steve Elmer

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A novel method for ECG signal classification via one-dimensional convolutional neural network, Xuan Hua, Jungang Han, Chen Zhao, Haipeng Tang, Zhuo He, Qinghui Chen, Shaojie Tang, Jinshan Tang, and Weihua Zhou

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Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans, M. L. Keller-Ross, Hannah Cunningham, and J. R. Carter

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The influence of thermal alterations on prefrontal cortex activation and neuromuscular function during a fatiguing task, Kevin Phillips, Derek Verbrigghe, Alex Gabe, Brittany Jauquet, Claire Eischer, and Tejin Yoon

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Quantifying segmental contributions to center-of-mass motion during dynamic continuous support surface perturbations using simplified estimation models, Alison Schinkel-Ivy, Vicki Komisar, and Carolyn A Duncan

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Knee extension with blood flow restriction: Impact of cuff pressure on hemodynamics., Tyler J Singer, Jon Stavres, Steven J. Elmer, Matthew A Kilgas, Brandon S Pollock, Sarah G Kearney, and John McDaniel

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Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in intact female versus male and ovariectomized female rats., Kevin P Uribe, Victor L Correa, Briana E Pinales, Rodolfo J Flores, Bryan Cruz, Zhiying Shan, Adriaan W Bruijnzeel, Arshad M Khan, and Laura E O'Dell

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Infographic. Stay physically active during COVID-19 with exercise as medicine, Isaac J. Wedig, Tristan A. Duelge, and Steven J. Elmer

Works from 2019

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Gut microbiota and short chain fatty acids: Influence on the autonomic nervous system, Jill N. Bruning, Andrew Chapp, Gregory Kaurala, Renjun Wang, Stephen Techtmann, and Qing-Hui Chen

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An outside-the-box activity to demonstrate how humans and animals turn, Thomas K. Bye, Kathryn R. Carter, David R. Carrier, and Steven J. Elmer

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Operational and Fiscal Management of Core Facilities: A Survey of Chief Research Officers, Jason R. Carter, Douglas Delahanty, Jane Strasser, Alicia J. Knoedler, Gillian Wilson, Ralph K. Davis, and Don Engel

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Sympathetic neural responsiveness to sleep deprivation in older adults: sex differences, Jason R. Carter, Ida Tchuisseu Fonkoue, Ian Greenlund, Christopher E. Schwartz, Babak Mokhlesi, and Carl Smoot

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Autonomic regulation of the cardiovascular system: Diseases, treatments, and novel approaches, Zixi Cheng, Renjun Wang, and Qing-Hui Chen

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0223 Total sleep deprivation and pain perception during cold noxious stimuli in older adults, Hannah Cunningham, Ian Greenlund, Ida Tchuisseu Fonkoue, Carl Smoot, and Jason R. Carter

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Acute Effects of Vaporized Nicotine Inhalation on Young Non-Smokers, Joshua Gonzalez, Stephanie Renee Jewell, and William H. Cooke

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0220 Total sleep deprivation decreases cardiac vagal activity, Ian Greenlund, Hannah Cunningham, Elizabeth Bloch, Anne Tikkanen, William H. Cooke, and Jason R. Carter

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0220 Total Sleep Deprivation Decreases Cardiac Vagal Activity, Ian Greenlund, Hannah Cunningham, Elizabeth Bloch, Anne Tikkanen, William H. Cooke, and Jason R. Carter

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0069 Spectral analyses of slow wave sleep and rapid eye movement sleep are associated with changes in continuous nocturnal blood pressure, Ian Greenlund, Hannah Cunningham, Anne Tikkanen, John J. Durocher, Carl Smoot, and Jason R. Carter

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Chronic standing desk use and arterial stiffness, Ian Greenlund, Piersan E. Suriano, Steven J. Elmer, Jason R. Carter, and John J. Durocher

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Insomnia and cardiovascular autonomic control, Daniela Grimaldi, Michael Goldstein, and Jason R. Carter

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Home-Based Exercise With Blood Flow Restriction to Improve Quadriceps Muscle and Physical Function After Total Knee Arthroplasty: A Case Report., Matthew A. Kilgas, Alicia E Denherder, Lydia Lytle, Cameron T Williams, and Steven J. Elmer

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Exercise with blood flow restriction to improve quadriceps function long after ACL reconstruction, Matthew A. Kilgas, Lydia Lytle, Scott N. Drum, and Steven J. Elmer

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Limb blood flow and tissue perfusion during exercise with blood flow restriction., Matthew A. Kilgas, John McDaniel, Jon Stavres, Brandon S Pollock, Tyler J Singer, and Steven J. Elmer

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Individual, task, and environmental influences on balance recovery: a narrative review of the literature and implications for preventing occupational falls, Vicki Komisar, William E. McIlroy, and Carolyn A Duncan

Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture, Dhavan Sharma, Wenkai Jia, Fei Long, Shweta Pati, Qing-Hui Chen, Bruce P. Lee, Chang Kyoung Choi, Feng Zhao, and et. al.

Works from 2018

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Acetate mediates alcohol excitotoxicity in dopaminergic-like PC12 cells, Andrew Chapp, Jessica Behnke, Kyle Michael Driscoll, Yuanyuan Fan, Eileen Hoban, Zhiying Shan, Li Zhang, and Qing-Hui Chen

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Energy cost associated with moving platforms., Carolyn A Duncan, Scott N MacKinnon, Jacques F Marais, and Fabien A Basset

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Eccentric arm cycling: A potential exercise for wheelchair users, Lydia Lytle, Jennifer L. Dannenbring, Matthew A. Kilgas, and Steven J. Elmer

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Sex differences in mechanisms of recovery after isometric and dynamic fatiguing tasks, Jonathon Senefeld, Hugo Pereira, Nicholas Elliott, Tejin Yoon, and Sandra Hunter

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Upregulation of Nav1.6 expression in the rostral ventrolateral medulla of stress-induced hypertensive rats., Jia-Xiang Wu, Lei Tong, Li Hu, Chun-Mei Xia, Min Li, Qing-Hui Chen, Fu-Xue Chen, and Dong-Shu Du