Date of Award


Document Type

Master's Thesis

Degree Name

Master of Science in Biomedical Engineering (MS)

College, School or Department Name

Department of Biomedical Engineering


Keat G. Ong


Fibroblast encapsulation is a stage of the wound healing process in which the implanted device is separated from the biological environment due to the formation of fibrotic tissue. Uncontrolled adhesion of fibroblasts, called fibrosis, has the ability to inhibit an implanted device’s functionality over its lifetime. Over time, fibroblasts have been shown to cause loosening and failure of bone-anchor implants which could include the possibility of harming the patient. The encapsulating process could also hinder the sensitivity of implanted biosensors operating in the body for continuous monitoring. Unfortunately, the antifouling surfaces which are commonly used on implanted devices to control the fibrotic response are not able to maintain their efficiency over an extended period of time and have a possibility to disrupt the device’s functionality. This project presents the development of a cell morphology analysis tool and an in vitro ultrasound system to investigate the effect of ultrasound on cell adhesion with the possibility of leading to further work in the control of fibroblast adhesion and prolonging the function and life of the implanted devices.