Date of Award
2012
Document Type
Master's Thesis
Degree Name
Master of Science in Chemistry (MS)
College, School or Department Name
Department of Chemistry
Advisor
Lanrong Bi
Abstract
With the number of ischemia reperfusion (I/R) injuries on the rise, and a lack of pharmacological intervention aimed at reducing free radical damage associated with I/R, we have developed 30 indole phenolic antioxidants that were synthesized by click chemistry to couple our indole with a phenolic or anisole derivative. The total antioxidant activity of the analogues was tested in vitro using the ferric thiocyanate lipid emulsion method. Compounds containing hydroxyl or methoxy aromatics at the 3 or 4 position on the aromatic coupled to the indole exhibited increased antioxidant scavenging. 4-methoxyindole derivatives (8a-e) exhibited increased scavenging (p < 0.05) compared to the known antioxidant butylated hydroxyanisole (BHA).
Recommended Citation
Chapp, Andrew, "Indole based antioxidants for the treatment of ischemia reperfusion injury", Master's Thesis, Michigan Technological University, 2012.