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Date of Award


Document Type

Campus Access Master's Report

Degree Name

Master of Science in Biological Sciences (MS)

Administrative Home Department

Department of Biological Sciences

Advisor 1

Xiaoqing Tang

Committee Member 1

Tarun Dam

Committee Member 2

Ebenezer Tumban


Diabetes mellitus is a group of metabolic diseases that are characterized by impaired glucose homeostasis that leads to elevated blood glucose. The two most important hormones in glucose metabolism and regulation are insulin and glucagon. These hormones are secreted by pancreatic beta-cells and alpha-cells respectively. Previous studies in our lab have shown that microRNA 483 (miR-483) is highly expressed in beta-cells but expressed at much lower levels in alpha-cells, and increased miR-483 induces insulin production and cell proliferation in beta-cells. In addition, expression of miR-483 is upregulated by KLF2 (Krüppel-like Factor 2), a zinc finger transcription factor that is involved in a broad range of cellular processes including cell differentiation, cell survival and anti-inflammatory. In this study we focus on the function of miR-483 and the regulation of miR-483 by Krüppel-like Factor 2 (Klf2) in alpha-cells.