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Date of Award
Campus Access Master's Report
Master of Science in Biological Sciences (MS)
Administrative Home Department
Department of Biological Sciences
Committee Member 1
Committee Member 2
Diabetes mellitus is a group of metabolic diseases that are characterized by impaired glucose homeostasis that leads to elevated blood glucose. The two most important hormones in glucose metabolism and regulation are insulin and glucagon. These hormones are secreted by pancreatic beta-cells and alpha-cells respectively. Previous studies in our lab have shown that microRNA 483 (miR-483) is highly expressed in beta-cells but expressed at much lower levels in alpha-cells, and increased miR-483 induces insulin production and cell proliferation in beta-cells. In addition, expression of miR-483 is upregulated by KLF2 (Krüppel-like Factor 2), a zinc finger transcription factor that is involved in a broad range of cellular processes including cell differentiation, cell survival and anti-inflammatory. In this study we focus on the function of miR-483 and the regulation of miR-483 by Krüppel-like Factor 2 (Klf2) in alpha-cells.
Rodriguez, Pedro, "THE ROLE OF KLF2/MIR-483/IGF2 IN PANCREATIC α-CELLS", Campus Access Master's Report, Michigan Technological University, 2017.