Synthesis of 3-Amino-2,2-dimethyl-8-thia-1-azaspiro[4.5]decane

Authors

Wenpeng Mai, Michigan Technological University
Sarah A. Green, Michigan Technological UniversityFollow
Dallas K. Bates, Michigan Technological UniversityFollow
Shiyue Fang, Michigan Technological UniversityFollow

Document Type

Article

Publication Date

8-5-2010

Abstract

The synthesis of 3-amino-2,2-dimethyl-8-thia-1-azaspiro[4.5]decane is described. Key steps include the addition of prenyl magnesium bromide to a 4-methoxybenzylimine without reversal of stereochemistry and the iodine-initiated aminocyclization to form the azaspirocycle.

Publisher's Statement

Publisher's version of record: http://dx.doi.org/10.1080/00397910903289255

Publication Title

Synthetic Communications

Recommended Citation

Mai, W., Green, S. A., Bates, D. K., & Fang, S. (2010). Synthesis of 3-Amino-2,2-dimethyl-8-thia-1-azaspiro[4.5]decane. Synthetic Communications, 40(17), 2571-2577. http://doi.org/10.1080/00397910903289255
Retrieved from: https://digitalcommons.mtu.edu/chemistry-fp/75