Synthesis of 3-Amino-2,2-dimethyl-8-thia-1-azaspiro[4.5]decane
The synthesis of 3-amino-2,2-dimethyl-8-thia-1-azaspiro[4.5]decane is described. Key steps include the addition of prenyl magnesium bromide to a 4-methoxybenzylimine without reversal of stereochemistry and the iodine-initiated aminocyclization to form the azaspirocycle.
Mai, Wenpeng; Green, Sarah A.; Bates, Dallas K.; and Fang, Shiyue, "Synthesis of 3-Amino-2,2-dimethyl-8-thia-1-azaspiro[4.5]decane" (2010). Department of Chemistry Publications. 75.