Mesenchymal stem cells for pre-vascularization of engineered tissues

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Engineered tissues with a thickness larger than 150μm require an embedded functional vascular network to support cell survival and integration with host vasculature after in vivo implantation. Mesenchymal stem cells (MSCs) can secrete trophic factors to promote angiogenesis and function as pericytes to stabilize endothelial cell engineered neo-capillary structures. Recently, studies have shown that co-culturing MSCs with endothelial cells (ECs) could develop a pre-capillary network in tissue scaffolds. To realize such an outcome, several factors need to be considered, including MSC source, cell seeding order, oxygen concentration, and extra cellular matrix features. The present mini review summarizes these crucial considerations and will provide beneficial references for successful development of functional pre-vascularized tissues.

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© 2018 Sharma et al. Article deposited here in compliance with publisher policies. Publisher's version of record: https://dx.doi.org/10.15406/jsrt.2018.04.00112

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Journal of Stem Cell Research & Therapeutics

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Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License


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