Potential of determining thermal dose for ablation therapies using ultrasound elastography: An ex vivo feasability study

Document Type

Conference Proceeding

Publication Date



Thermal ablation therapy is a minimally invasive technique with the potential to allow eradication of tumors utilizing highly localized heating. Protein coagulation induced by heating is thought to induce a change at the microscopic level, thereby manifesting itself as measurable macroscopic changes of the tissue's viscoelastic properties. The objective of this study was to determine the relationship between clinically relevant thermal doses and a novel biomechanical parameter measurable using ultrasound. Ex vivo porcine liver tissue samples were administered clinically relevant thermal doses via a temperature-controlled double immersive water bath. Stress and strain data obtained from unconfined uniaxial compression and stress-relaxation tests were fit to a Kelvin-Voigt fractional derivative (KVFD) model of tissue viscoelasticity. In the KVFD model, the alpha parameter is the order of the fractional derivative (0<;a

Publisher's Statement

Publisher's version of record: http://doi.org/10.1109/ULTSYM.2018.8579670

Publication Title

2018 IEEE International Ultrasonics Symposium (IUS)